Aston Villa and Chelsea drop crucial points in the Premier League as Leeds and Burnley earn draws; James Milner sets appearance record.
Promoted Sunderland, who have defied expectations to stay in the top half of the Premier League table, could be the worst affected with six players going to the tournament, while the likes of Fulham, Manchester United, Burnley and Crystal Palace will also have to make do without some key personnel.
Images from the EPL matches played on Saturday.
Manchester United secured the point they needed to finish second in the Premier League with a dull 0-0 draw at West Ham United on Thursday.
A summary of Saturday's action in the Premier League.
Manchester United fought back to overpower West Ham United 3-1 and reach the FA Cup quarter-finals.
Second-placed City would have reduced Arsenal's advantage to two points but instead were frustrated as their winning streak in all competitions was halted at eight.
'...So that tells you the resilience, resources, the ambition the team has.'
The Egypt forward has been left out of the club's Champions League match against Inter Milan.
Championship side Oxford United beat League Two's MK Dons on penalties after their match ended 1-1, while a couple of League One teams moved on, with Wigan Athletic beating Championship side Preston North End 1-0, and Port Vale defeating League Two's Fleetwood Town 1-0.
Ruben Amorim is set to become the next manager of Manchester United with the Premier League club prepared to pay Sporting the 10 million euros ($10.79 million) release clause, the Portuguese club said on Tuesday.
Tottenham's task was made all the more difficult two minutes before the interval when forward Son Heung-min was sent off
A round-up of Saturday's action in the Premier League.
IMAGES from the Premier League matches played on Tuesday.
Newcastle United registered a 2-0 home win over Chelsea on Sunday that moves the Magpies a step closer to Champions League football next season.
IMAGES from the UEFA Champions League matches played on Tuesday
Should Manchester United win their next two games, the gap will be cut to four points and while only a collapse of astonishing proportions would deny Manchester City the title.
Man United boss Amorim says he has no plans to quit
Premier League leaders Arsenal needed two own goals, the second deep in stoppage time, to scrape a 2-1 home win over bottom club Wolverhampton Wanderers and open a five-point gap, while earlier on Saturday Mohamed Salah put aside a tumultuous week to help Liverpool beat Brighton and Hove Albion 2-0.
Manchester United's troubled season hit a new low on Saturday as Jose Mourinho saw his gamble on introducing a new tactical system backfire with an insipid 3-1 defeat to West Ham United in the Premier League.
IMAGES from Premier League matches played on Sunday.
United are 13th in the Premier League table and following a 1-1 draw with Dutch side Twente Enschede in the first Europa League match, Ten Hag said speculation about his job was inevitable.
Daley Blind's injury-time equaliser rescued a 1-1 draw for Manchester United against West Ham United on Sunday but a point was not enough to regain third spot in the Premier League.
Nearly two decades later, Aditi Chauhan retires as a trailblazer, having become the first Indian woman to play professional football in Europe.
Tottenham Hotspur missed the chance to move into the top four when they were held to a 1-1 draw at West Ham United
Images from Sunday's action in the Premier League
Ruud van Nistelrooy will take over on an interim basis.
West Ham United have condemned the behaviour of some of their fans after Fiorentina's Cristiano Biraghi was hit by a cup during the Europa Conference League final.
Manchester United were humbled 3-0 at home by Newcastle United in the League Cup fourth round
A brilliantly-worked goal by Ryan Christie and a Justin Kluivert penalty gave Bournemouth shock 2-0 Premier League win at home to 10-man Arsenal.
The other semi-final will see an Italian side, Milan or Roma, come up against Bayer Leverkusen or West Ham.
Pep Guardiola has apologised to Kalvin Phillips for saying the midfielder was overweight
Fresh off a dominant title-winning campaign, Liverpool kick off the new Premier League season on Friday as the team to beat, as the Reds have transitioned from Juergen Klopp's high-octane chaos to a more measured possession-based style under Arne Slot.
Sunderland and West Bromwich Albion stayed in touch with the Premier League leaders with solid home wins over West Ham United and Newcastle United on Sunday.
Manchester City took another decisive step toward an unprecedented fourth successive Premier League title with a 4-0 demolition of Fulham.
Arsenal snapped a season-long jinx against Newcastle United with a nervy 1-0 win in their last Premier League home game on Sunday.
Images from the English Premier League matches played on Sunday.
IMAGES from the Premier League matches played on Tuesday.
Ryan Giggs scored a sublime goal to seal a 1-0 win for Manchester United at West Ham United on Sunday that sent them back to the top of the Premier League.
Manchester United suffered a stinging 2-1 home defeat by Swansea City in the FA Cup third round on Sunday as their former fortress of Old Trafford was ransacked for the fifth time this season.
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